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Coronaviruses evolve to optimize receptor recognition in their natural hosts. A key mystery of COVID-19 is why the SARS-CoV-2 receptor-binding domain (RBD) binds human ACE2 with such high affinity despite limited time for adaptation, while some bat

COV-SARS-2 targets alveolar type II cells. As these cells synthesise lung surfactant, we hypothesised that surfactant dysfunction may contribute to development of ARDS in COVID-19. Here we report turnover of surfactant delivered to patients

CONCLUSION: Switching from daily combustible cigarette smoking to dual use with heated tobacco products may increase the risk of severe periodontitis. Combining combustible cigarettes with heated tobacco products, regardless of the frequency of

No abstract

CONCLUSIONS: The timing of pSBS aligns with pVL, and pVL above 170,000,000 RNA copies/ml predicts prolonged symptom duration. URT symptom escalation often marks the onset of infectiousness, while systemic symptoms, particularly muscle aches, signal

A novel tetra-substituted imidazole derivative (BDIM) was synthesized via a one-pot, four-component condensation reaction using BF(3) as a Lewis acid catalyst. The experimental FT-IR,¹H- and ¹³C-NMR spectra show a very good match with the DFT

CONCLUSIONS.: Homologous or heterologous vaccination platforms from three doses onwards do not modify IgG (anti-spike) antibody production; however, they improve CD8+ T cell values, which constitute the most important subpopulation for the antiviral

'Teleconsultation Connecting ALL patients in Remote Expanses' (TeleCARE) was introduced to ensure continuity of care for children with acute lymphoblastic leukemia (ALL) during the second wave of the COVID-19 pandemic; consultations were done via

This study aimed to analyze vaccination coverage temporal and spatial heterogeneities in the basic children schedule in the Brazilian Unified National Health System (SUS) in state capitals and macroregions from 2010 to 2021 by a new monitoring

CONCLUSIONS: Telemedicine use persists post-pandemic but reflects differences in access by age, race/ethnicity, socioeconomic status, and prior engagement with the patient portal. Targeted policies are needed to ensure equitable telemedicine adoption